To introduce in vivo multifrequency single-shot magnetic resonance elastography for full-FOV stiffness mapping of the mouse brain and to compare in vivo stiffness of neural tissues with different white-to-gray matter ratios.

Brain mechanical properties influence many vital neurological functions including brain development, metabolism, and tissue repair. However, studying brain mechanical properties in a noninvasive fashion encounters a number of challenges including the fact that the brain is protected by the skull as well as the heterogeneous and complex geometry of the brain. At present, magnetic resonance elastography (MRE) is the sole modality allowing noninvasive measurement of in vivo brain mechanical properties in patients and small animals.