In this paper, a vibration-assisted needle insertion technique has been proposed in order to reduce needle–tissue friction. The LuGre friction model was employed as a basis for the current study and the model was extended and analyzed to include the impact of high-frequency vibration on translational friction. Experiments were conducted to evaluate the role of insertion speed as well as vibration frequency on frictional effects. In the experiments conducted, an 18 GA brachytherapy needle was vibrated and inserted into an ex-vivo soft tissue sample using a pair of amplified piezoelectric actuators. Analysis demonstrates that the translational friction can be reduced by introducing a vibratory low-amplitude motion onto a regular insertion profile, which is usually performed at a constant rate.